Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381
نویسندگان
چکیده
منابع مشابه
Crystal structure of cytochrome P450 MoxA from Nonomuraea recticatena (CYP105).
Cytochrome P450 MoxA (P450moxA) from a rare actinomycete Nonomuraea recticatena belongs to the CYP105 family and exhibits remarkably broad substrate specificity. Here, we demonstrate that P450moxA acts on several luciferin derivatives, which were originally identified as substrates of the human microsomal P450s. We also describe the crystal structure of P450moxA in substrate-free form. Structur...
متن کاملAnthelmintic Activity of Punicalagin from Anogeissus Leiocarpus
Leaves of Anogeissus leiocarpus Guill. & Perr. have been traditionally used as an African botanical treatment for parasitic worm infections in both humans and livestock. This current study documents the presence of punicalagin isomers (α & β) and its galloyl ester, 1-O-galloyl-punicalagin as major components in the leaf extract of A. leiocarpus. Identification was performed using HPLC and LC-io...
متن کاملAnthelmintic acetogenin from Annona squamosa L. Seeds.
Annona squamosa seeds extracts showed anthelmintic activity against Haemonchus contortus, the main nematode of sheep and goat in Northeastern Brazil. A compound 1 was isolated from ethyl acetate extract and inhibited the egg hatching of H. contortus at 25 mg ml(-1). The structure of 1 was determined as a C37 trihydroxy adjacent bistetrahydrofuran acetogenin based on spectroscopic analysis.
متن کاملMacrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.
Bioassay-guided metabolomic analyses led to the characterization of four new 20-membered glycosylated polyketide macrolactams, macrotermycins A-D, from a termite-associated actinomycete, Amycolatopsis sp. M39. M39's sequenced genome revealed the macrotermycin's putative biosynthetic gene cluster. Macrotermycins A and C had antibacterial activity against human-pathogenic Staphylococcus aureus an...
متن کاملAnthelmintic Resistance
Parasitic gastroenteritis, caused by roundworms (nematodes), is well recognised as a major production-limiting disease, particularly in lambs. Effective parasite control has become heavily dependent on anthelmintics. The development of anthelmintic resistance by roundworms poses a potential crisis for sheep producers and measures to avert and delay this are essential. This report summarises the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2008
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2008.110